Prediction of regulatory SNPs influencing Gene expression on Chromosome 5q31-33

Transcription regulation is one of the most basic regulatory mechanisms in the cell. It is controlled by transcription factors which binds on a specific sequence called transcription factor binding site(TFBS). In the field of gene expression regulation, researches on TFBS binding TF have been actively going on. Searching methods for TFBS frequently use position-specific frequency matrices for base scoring at a binding site. In this study, we predicted TFBS on chromosome 5q31-33 and mapped SNP in the TFBS. We analyzed whether or not the transcription factor binding was affected by SNP allele change of TFBS.